ACTG research projects are examining novel proteins that regulate responses to ethanol in ex vivo, rodent or invertebrate studies. These proteins have not been examined by alcohol researchers before. ACTG investigators use preclinical rodent models to determine if these proteins regulate behavioral responses to ethanol and contribute to alcohol use disorders. Such studies are necessary to determine if any of these proteins are potential drug targets for the development of new therapies to treat alcoholism and if they contribute to genetic risk of alcoholism.
Discovering new approaches to pharmacologic treatment
and detection of risk for alcohol use disorders.
Of the 18 research centers funded by the National Institute on
Alcohol Abuse and Alcoholism, the ACTG focuses on validating new candidate genes as targets for
therapeutics and as risk factors for alcohol use disorders.
The ACTG supports the coordinated research efforts of 20 scientists within the Ernest Gallo Clinic and Research Center in the Department of Neurology at the University of California, San Francisco, in areas ranging from behavioral and systems neuroscience, molecular and cell biology, and genetics.
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